Journal of Asia Pacific Aesthetic Sciences

Abstract: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer globally, with incidence rates varying across different regions. This case report describes a 72-year-old Chinese woman with extensive vitiligo and Fitzpatrick skin type II who presented with suspicious lesions on her scalp and cheek. Upon examination, the lesions exhibited distinct morphologies, and histopathological analysis confirmed invasive squamous cell carcinoma on the scalp and verrucous carcinoma on the cheek. The diagnosis was established through a punch biopsy of the scalp lesion and excision of a cutaneous horn on the right cheek. The patient subsequently underwent wide local excision and was referred for oncologic evaluation. The occurrence of cSCC in patients with vitiligo is rare, and most studies suggest these individuals have a lower risk of skin cancer. However, this case highlights the development of cSCC in a vitiligo patient, emphasizing the importance of increasing patient awareness, particularly regarding skin self-examination, early medical consultation, and sun protection. These factors are crucial for early detection and improving outcomes. Early recognition, prompt biopsy of atypical lesions, and ongoing dermatologic surveillance ensure timely diagnosis and effective management.