Journal of Asia Pacific Aesthetic Sciences

ABSTRACT: A topical skin pigmentation-balancing (SPB) kit containing kojic acid and glycolic acid has previously been evaluated in individuals with Fitzpatrick skin phototypes II–III. This case series aimed to assess the efficacy and safety of the SPB kit in women of Asian origin with melasma and Fitzpatrick skin phototype IV. Ten patients were treated individually over a period ranging from 2 to 24 months. Clinical assessments were performed at baseline and at the final visit using a melanin index (MI) derived from a melanometer and the modified Melasma Area and Severity Index (mMASI). Additional evaluations included dermoscopic assessment, QuantifiCare medical imaging system analysis, and Physician’s Global Assessment scores to further explore their utility in skin pigmentation studies. Mean melanin index and mMASI scores decreased in all patients, with consistent improvement observed across all secondary outcome measures. Patients reported satisfaction with the treatment, and no treatment-related adverse events were observed. This is the first case series evaluating the SPB kit in patients with Fitzpatrick skin phototype IV, demonstrating its efficacy and tolerability.