ABSTRACT: Demodicosis is a skin disease caused by mites of the genus Demodex. Some evidence suggests that these mites may contribute to flare-ups in patients with rosacea. We report a case of a 32-year-old healthy male who developed multiple, irregularly shaped, well-defined erythematous macules, papules, pustules and scaly plaques infested with Demodex mites over the zygomatic and centrofacial (glabellar) areas of the face. The patient was treated with permethrin 5% cream twice daily for two months, and low-dose oral isotretinoin at 10 mg/day for two months, resulting in significant clinical improvement. The combination of permethrin 5% cream and low-dose oral isotretinoin may be considered a potential treatment option for Demodex folliculitis on a background of rosacea.