Journal of Asia Pacific Aesthetic Sciences

Abstract: Melasma is a common hyperpigmentation disorder that poses a significant challenge in terms of effective treatment. Conventional therapies often yield limited success, necessitating the exploration of alternative modalities. This case report demonstrates the efficacy of a dual yellow laser (511 nm and 578 nm) in combination with oral tranexamic acid and topical anti-pigment cream in the treatment of melasma. A 38-year-old Chinese woman with a 2-year history of melasma had previously sought multiple laser treatments at beauty centres but achieved unsatisfactory results. She opted for the Norseld dual yellow laser due to its minimal downtime and comfort. Due to financial constraints, she underwent four sessions of dual yellow laser (settings as per manufacturer protocol), two months of oral tranexamic acid, and depigmentation cream (5% tranexamic acid/alpha arbutin 2%). The mMASI score was reduced from 3.6/24 to 0.6/24 after four sessions of treatment. No side effects were reported following the yellow laser treatment. It can be concluded that the combination of dual yellow laser, oral tranexamic acid, and depigmentation cream holds promise as an effective and safe treatment modality for melasma. Further research and larger clinical studies are warranted to validate these findings.