Journal of Asia Pacific Aesthetic Sciences

Abstract: Amyloidosis cutis dyschromica (ACD) is a rare form of primary cutaneous amyloidosis, first described by Morishima in 1970. Fewer than 100 cases have been documented in medical literature, with under 10 patients reported from the Philippines. It presents as widespread macular, reticular hyperpigmentation and hypopigmentation, often appearing before puberty and accompanied by focal subepidermal amyloid deposits. We report a case of ACD in a 35-year-old Filipino woman presenting with asymptomatic dyschromic skin lesions, with the primary aim of aiding dermatologists in recognizing this rare but benign condition.

Keywords: Amyloidosis cutis dyschromica, Cutaneous amyloidosis, Dyschromia, Hyperpigmentation, Hypopigmentation, GPNMB mutation