Abstract: Confluent and reticulated papillomatosis (CARP) is an acquired ichthyosiform disorder characterized by hyperpigmented papules that coalesce into plaques, often displaying reticulated patterns along the periphery. It typically affects the upper trunk and neck, particularly in adolescents and young adults. Due to its close clinical resemblance, CARP is frequently misdiagnosed as acanthosis nigricans or pityriasis versicolor. Although oral minocycline remains the mainstay of treatment, oral isotretinoin has also shown effectiveness, as evidenced by reductions in scaling and pigmentation of lesions. This case series describes two female Filipino patients with CARP who were successfully treated with low-dose isotretinoin.

Keywords: Confluent and reticulated papillomatosis, Isotretinoin, Acanthosis nigricans