Abstract: Hypopigmented mycosis fungoides (HMF) is a rare variant of cutaneous T-cell lymphoma that predominantly affects children and individuals with darker skin. We report two Filipino patients, a 4-year-old girl and a 34-year-old man, who presented with progressive, non-pruritic hypopigmented patches. Histopathology and immunohistochemistry confirmed HMF, revealing CD8+ predominance in the pediatric case and CD3+ epidermotropic cells in the adult. The child demonstrated a favorable response to narrowband UVB phototherapy, while the adult showed early improvement with topical corticosteroids. These cases underscore the importance of considering HMF in persistent hypopigmented dermatoses and highlight the value of clinicopathologic correlation for timely diagnosis and management.

Keywords: Hypopigmented mycosis fungoides, Cutaneous lymphoma, Epidermotropism, Phototherapy