Abstract: We present three cases of rhinophyma in three Filipino gentlemen in terms of clinical, dermoscopy and histopathologic characteristics. All 3 patients were prescribed low dose oral isotretinoin with a combination of long pulsed 1064-nm neodymium-yttrium aluminum-garnet (Nd:YAG) laser treatments. Two of the patients further underwent bulk ablation by carbon dioxide laser. A combination of low dose oral isotretinoin 0.3 mg/kg/day and long pulsed Nd-YAG 1064nm laser utilizing vascular and hair removal parameters resulted to a rapid remission and dramatic improvement after 6 months of treatment and after 6 months follow-up. This treatment combination is promising and has not yet been described in the literature.