Journal of Asia Pacific Aesthetic Sciences

Abstract: Stem cells secretome is a wide term for the complex group of chemicals produced by stem cells, including growth factors and cytokines. It promotes wound healing by it's immunomodulatory properties, stimulating angiogenesis, acceleating skin reepithelisation and improving extracellular matrix production modelling. This is the first report of hUC-MSCs (Human umbilical cord mesenchymal stem cells) scretome application in wound management in the case of vascular occlusion after filler injection. A 49 years old gentleman had sustained vascular occlusion from filler injection over the forhead for aesthetic purposes. He suffered from ulcers, pustules and hyperpigmentation over his forehead. His wound had healed well after multiple secretome injections over the course of 4 months. The secretome of hUC-MSCs (Human umbilical cord mesenchymal stem cells) may be a potential therapeutic strategy for treating avascular wound.